详细描述

姓    名：    谭志杰 (Zhi-Jie Tan)
职务/职称：教 授（博士生导师）
电子邮箱： zjtan@whu.edu.cn
招生专业： 理论物理、医学物理、凝聚态物理

本课题组长期招收统计物理、医学物理、软物质物理和生物物理方向的博士后和博士硕士研究生。

教育与工作经历：
1996年获武汉大学理学学士，2001年获武汉大学博士学位，期间获中国科学院奖学金，博士学位论文获全国优秀博士论文提名奖和湖北省优秀博士论文。博士生期间留武汉大学任教，2001年破格晋升为副教授，后公派赴美国密苏里大学合作研究，并获得该校生命科学博士后奖学金。2008年6月回到武汉大学，晋升为教授，并被遴选为博士生导师。2008年入选教育部新世纪人才计划，2010年获国家自然科学二等奖（第三完成人），2011年获湖北省青年科技奖。主讲弘毅学堂物理班《热力学与统计物理》和研究生通开课《固体物理II》。担任中国物理学会软物质与生物物理专业委员会委员、全国统计物理与复杂系统会议学术委员会委员等，现为中国物理学会、美国生物物理学会、美国RNA学会等学会会员，现主持和完成国家自然科学基金项目多项。

研究兴趣：
1，发展物理模型，预测RNA、DNA三维结构、热力学及其中离子静电效应；
2，发展高性能RNA结构评估势能函数和RNA-药物小分子结合势能函数模型；
3，发展高性能RNA三维结构拼装模型和RNA三维结构优化模型;
4，利用计算机模拟，预测和理解DNA、RNA结构与力学弹性及其微观机制。

受邀综述:
1. Tan et al. Statistical potentials for 3D structure evaluation: from proteins to RNAs. Chin Phys B 30: 028705 (1-13), 2021.
2. Bao et al. Flexibility of nucleic acids: from DNA to RNA. Chin Phys B 25: 018703 (1-11), 2016. (2018 CPB high citation article)
3. Tan et al. RNA folding: structure prediction, folding kinetics and ion electrostatics. Adv Expt Med & Biol 827:143-183, 2015.
4. Shi et al. RNA structure prediction: Progress and perspective. Chin Phys B 23: 078701(1-10), 2014.
5. Tan & Chen. Importance of Diffuse Metal Ion Binding to RNA, 9:101-124. in "Structural and Catalytic Roles of Metal Ions in RNA" (volume of Metal Ions in Life Sciences), edited by Astrid Sigel, Helmut Sigel, and Roland K. O. Sigel. 2011.  
6. Tan & Chen. Predicting electrostatic forces in RNA folding, 469:465-487, in "Biophysical Approaches to RNA Structure and Folding" (volume of Methods in Enzymology), edited by Daniel Herschlag. 2009.

代表性研究论文 (第一或通讯作者):
1.   Qiang et al. Multivalent cations reverse the twist-stretch coupling of RNA. Phys Rev Lett 128, 108103, 2022
2.   Tan et al. rsRNASP: A residue-separation-based statistical potential for RNA 3D structure evaluation. Biophys J. 121:142-156, 2022. (New and Notable article)
3.   Feng et al. Salt-Dependent RNA pseudoknot stability: effect of spatial confinement. Front Mol Biosci. 8:666369, 2021
4.   Fu et al. Opposite Effects of high-valent cations on the elasticities of DNA and RNA duplexes revealed by magnetic tweezers. Phys Rev Lett 124: 058101, 2020.
5.   Wang et al. Salt effect on thermodynamics and kinetics of a single RNA base pair. RNA. 26: 470-480, 2020.
6.   Jin et al. Structure folding of RNA kissing complexes in salt solutions: predicting 3D structure, stability and folding pathway. RNA. 25:1532-1548, 2019;
7.   Lin et al. Apparent repulsion between equally and oppositely charged spherical polyelectrolytes in symmetrical salt solutions. J Chem Phys 151, 114902, 2019;
8.   Liu et al. Structural flexibility of DNA-RNA hybrid duplex: stretching and twist-stretch coupling. Biophys J 117:74-86, 2019;
9.   Tan et al. What is the best reference state for building statistical potentials in RNA 3D structure evaluation? RNA. 25: 793-812, 2019;
10. Jin et al. Modeling structure, stability, and flexibility of double-stranded RNAs in salt solutions. Biophys J 115: 1403-1416, 2018;
11. Shi et al. Predicting 3D structure and stability of RNA pseudoknots in monovalent and divalent ion solutions. PloS Comput Biol 14: e1006222, 2018;
12. Xi et al. Competitive binding of Mg2+ and Na+ ions to nucleic acids: from helices to tertiary structures. Biophys J 114: 1776-1790, 2018;
13. Zhang et al. Potential of mean force between oppositely charged nanoparticles: A comprehensive comparison between Poisson– Boltzmann theory and Monte Carlo simulations. Sci Rep 7: 14145, 2017;
14. Zhang et al. Divalent ion-mediated DNA-DNA interactions: A comparative study of triplex and duplex. Biophys J 113:517-528, 2017. (Highlighted article);
15. Zhang et al. Radial distribution function of semiflexible oligomers with stretching flexibility. J Chem Phys 147:054901, 2017. (Featured article);
16. Bao et al. Understanding the relative flexibility of RNA and DNA duplexes: stretching and twist-stretch coupling. Biophys J 112:1094-1104, 2017;
17. Zhang et al. Potential of mean force between like-charged nanoparticles: many-body effect. Sci Rep 6: 23434 (1-12), 2016;
18. Shi et al. Predicting 3D structure, flexibility and stability of RNA hairpins in monovalent and divalent ion solutions. Biophys J 109: 2654-2665, 2015;
19. Wu et al. Multivalent ion-mediated nucleic acid helix-helix interactions: RNA versus DNA. Nucleic Acids Res 43: 6156-6165, 2015.
20. Wu et al. Flexibility of short DNAs with finite-length effect: from base pairs to tens of base pairs. J Chem Phys 142: 125103(1-13), 2015;
21. Shi et al. A coarse-grained model with implicit salt for RNAs: Predicting 3D structure, stability and salt effect. J Chem Phys 141:105102(1-13), 2014.
22. Wang et al, Salt contribution to the flexibility of single-stranded nucleic acid of finite length. Biopolymers 99:370–381, 2013. (Cover picture);
23. Tan & Chen. Ion-mediated RNA structural collapse: effect of spatial confinement. Biophys J 103:827-836, 2012;
24. Tan & Chen. Salt contribution to RNA tertiary structure folding stability. Biophys J 101:176-187, 2011;
25. Tan & Chen. Predicting ion binding properties for RNA tertiary structures. Biophys J 99:1565-1576, 2010 ;
26. Tan & Chen. Salt dependence of nucleic acid hairpin stability. Biophys J 95:738-752, 2008;
27. Tan & Chen. Electrostatic free energy landscapes for DNA helix bending. Biophys J 94:3137-3149, 2008;
28. Tan & Chen. RNA helix stability in mixed Na+/Mg2+ solutions. Biophys J 92:3615-3632, 2007;
29. Tan & Chen. Electrostatic free energy landscapes for nucleic acid helix assembly. Nucleic Acids Res 34:6629-6639, 2006;
30. Tan & Chen. Ion-mediated nucleic acid helix-helix interactions. Biophys J 91:518-536, 2006;
31. Tan & Chen. Nucleic acid helix stability: effects of salt concentration, cation valency and size, and chain length. Biophys J 90:1175-1190, 2006;
32. Tan & Chen. Electrostatic correlation and fluctuations for ion binding to finite length polyelectrolyte. J Chem Phys 122:044903(1-16), 2005;
33. Tan et al. Pattern of particle distribution in multi-particle system by random walk with memory enhancement and decay. Phys Rev E 66:011101, 2002;
34. Tan et al. Deposition, diffusion and aggregation on percolations: A model for nanostructure growth on nonuniform substrates. Phys Rev B 65:235403, 2002;
35. Tan et al. Pattern formation on nonuniform surfaces by correlated-random sequential adsorption. Phys Rev E 65:057201, 2002;
36. Tan et al. Random walk with memorial enhancement and decay. Phys Rev E 65:041101, 2002;
37. Tan et al. Percolation with long-range correlations for epidemic spreading. Phys Rev E 62:8409-8412, 2000;
38. Tan et al. Structure transition in cluster-cluster aggregation under external fields. Phys Rev E 61:734-737, 2000;
39. Tan et al. Influence of particle size on diffusion-limited aggregation. Phys Rev E 60:6202-6205, 1999;
40. Tan et al. Influences of the size and dielectric properties of particles on electrorheological response. Phys Rev E 59:3177-3181, 1999.